Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs.Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways.RNF145 Art prints expression is induced in response to LXR activation and high-cholesterol diet feeding.Tran
Cerebrotendinous Xanthomatosis represents a rare and underdiagnosed inherited neurometabolic disorder due to homozygous or compound heterozygous variants involving the CYP27A1 gene.This bile acid metabolism disorder represents a key potentially treatable neurogenetic condition due to the wide spectrum of neurological presentations in which it most
We demonstrate an explicit numerical method for accurate calculation ofthe analytic continuation of the scattering matrix, describing the multichannelscattering by a quantum well, to the unphysical region of complexvalues of the energy.Results of calculations show that one or severalpoles of the S-matrix exist, corresponding to the over-barrier res
Hand-eye calibration enables FIRM HOLD HAIR SPRAY proper perception of the environment in which a vision guided robot operates.Additionally, it enables the mapping of the scene in the robots frame.Proper hand-eye calibration is crucial when sub-millimetre perceptual accuracy is needed.For example, in robot assisted surgery, a poorly calibrated robo